Acid Related Diseases: Biology and Treatment by Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD

By Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc

This textbook explores the background, biology, and remedy of acid similar ailments, together with gastric and duodenal ulcer disorder, gastroesophageal reflux ailment (GERD), and the function of H. pylori. The textual content deals thorough insurance of the subject material, with an in-depth ancient and organic concentration. equivalent concentration is given to the biology and pharmacology of acid secretion and to the categorical disorder states of ulcers and GERD. This variation is filled with new full-color clinical illustrations of all facets of this topic.

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Comput Appl Biosci 1994;10:685-686. Celsus AC. Of the disorders of the stomach and their cures. In: De Medicina, book IV. London: Wilson and Durham, 1756:196-201. Griene J, translator. Cyrklaff M, Auer M, Kuhlbrandt W, et al. 2-D structure of the Neurospora crassa plasma membrane ATPase as determined by electron cryomicroscopy. EMBO J 1995;14:1854-1857. Davies RE. The mechanism of hydrochloric acid production by the stomach. Biol Revs 1951;26:87. Dibona DR, Ito S, Berglindh T, et al. Cellular site of gastric acid secretion.

Cyrklaff M, Auer M, Kuhlbrandt W, et al. 2-D structure of the Neurospora crassa plasma membrane ATPase as determined by electron cryomicroscopy. EMBO J 1995;14:1854-1857. Davies RE. The mechanism of hydrochloric acid production by the stomach. Biol Revs 1951;26:87. Dibona DR, Ito S, Berglindh T, et al. Cellular site of gastric acid secretion. Proc Natl Acad Sci U S A 1979;76:6689. Feng J, Lingrel JB. Analysis of amino acid residues in the H5-H6 transmembrane and extracellular domains of Na,K-ATPase alpha subunit identifies threonine 797 as a determinant of ouabain sensitivity.

Using yeast two-hybrid analysis, two different sequences in the β subunit, Gln 64 to Val 126 and Ala 156 to Arg 188, were identified as containing association domains in the extracytoplasmic sequence of the β subunit. 32 The reactive sites of the catalytic subunit The gastric α subunit has conserved sequences along with the other P-type ATPases for the ATP-binding site, the phosphorylation site, the pyridoxal 5′-phosphate-binding site, and the fluorescein isothiocyanate (FITC)-binding site. These sites are in the ATP-binding domain in the large cytoplasmic loop between membrane-spanning segments 4 and 5.

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