Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Division on Engineering and

By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

Super detrimental components (EHSs)² might be published by chance because of chemical spills, commercial explosions, fires, or injuries related to railroad automobiles and vans transporting EHSs. staff and citizens in groups surrounding commercial amenities the place EHSs are synthetic, used, or kept and in groups alongside the nation's railways and highways are almost certainly vulnerable to being uncovered to airborne EHSs in the course of unintended releases or intentional releases by means of terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental safety service provider (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality info in rodents. As a part of its efforts to advance acute publicity instruction degrees for EHSs, EPA and the supplier for poisonous components and sickness Registry (ATSDR) in 1991 asked that the nationwide study Council (NRC) boost instructions for developing such degrees. in keeping with that request, the NRC released directions for constructing group Emergency publicity degrees for damaging components in 1993. for that reason, typical working tactics for constructing Acute publicity instruction degrees for harmful ingredients was once released in 2001, offering up to date approaches, methodologies, and different instructions utilized by the nationwide Advisory Committee (NAC) on Acute publicity guide degrees for detrimental ingredients and the Committee on Acute publicity guide degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently evaluation the AEGLs built via NAC. based on that request, the NRC equipped inside its Committee on Toxicology (COT) the Committee on Acute publicity guide degrees, which ready this record. Acute publicity instruction degrees for chosen Airborne chemical substances is the 10th quantity of the sequence and records for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.

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1994 IARC 1989 Saturated vapor pressure 3,755 ppm at 20°C 5,000 ppm at at 25°C Shell Oil Company 1982 Lundberg et al. 9445 Budavari et al. 33 ppm NIOSH 2005 20 Acute Exposure Guideline Levels 2. 1. Acute Lethality No acute lethality data in humans were found in the searched literature. 2. 1. Controlled Exposures DMF has a faint amine odor (Budavari et al. 1996). 47 to 100 ppm (EPA 1992). 47-ppm concentration was the threshold for recognition; no data were provided for the 100-ppm concentration.

A ranking sum value based on GGT, AST, and ALT levels was determined for all groups. The results demonstrated that chronic occupational DMF exposure can impair liver function, and drinking alcohol was synergistic with the hepatotoxicity of DMF. Catenacci et al. (1984) found no alterations in hepatic function in 54 workers employed for at least 5 years in an acrylic fiber plant and exposed to DMF at <10 ppm for 8-h TWAs. Hepatic parameters included assessment of serum ALT, AST, GGT, and AP. I. Dupont de Nemours & Co.

Sperm morphology was evaluated in males at necropsy, and vaginal cytology was investigated in females 2 weeks prior to necropsy by evaluating vaginal lavage fluid. All animals survived to study termination. It was noted that DMF was mildly irritating to rats exposed at 400 or 800 ppm, as indicated by occasional nasal and ocular discharges. Absolute body weight and body-weight gain were decreased in the 400- and 800-ppm males and females. Alterations in liver enzymes (ALT, SDH, and isocitrate dehydrogenase) and bile salts were present at the first analysis on day 4 in the 400- and 800-ppm males and females.

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