Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Board on Environmental Studies

By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels

This booklet is the 6th quantity within the sequence Acute publicity guide degrees for Selected Airborne Chemicals, and contains AEGLs for chemical substances resembling ammonia, nickel carbonyl and phosphine, between others.

At the request of the dept of safeguard, the nationwide learn Council has reviewed the appropriate clinical literature compiled by means of a professional panel and demonstrated Acute publicity guide degrees (AEGLs) for 12 new chemical substances. AEGLs characterize publicity degrees lower than which opposed well-being results aren't more likely to take place and are helpful in responding to emergencies akin to unintentional or intentional chemical releases locally, the place of work, transportation, the army, and for the remediation of infected sites.

Three AEGLs are licensed for every chemical, representing publicity degrees that bring about: 1) amazing yet reversible soreness; 2) long-lasting well-being results; and three) life-threatening health and wellbeing impacts.

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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6

Sample text

Concurrent Exposure Issues Inhalation exposure (whole-body) can also result in inadvertent exposure of the skin, which can potentially add significantly to allylamine toxicity. Several studies indicate that allylamine is absorbed through the skin and can cause acute lethality. 76 g/mL) on a 1-cm2 piece of toweling to the shaved abdominal skin of albino rats caused skin necrosis and death after 5-18 h (animal weight not given; Hart 1939). 025 mL (19 mg) of allylamine caused slight skin irritation.

Carcinogenicity No studies on the carcinogenicity of allylamine in animals were located. Neither EPA nor IARC has classified allylamine as to carcinogenicity. The allylamine metabolite acrolein EPA weight-of-evidence characterization, under the 1999 Draft Revised Guidelines for Carcinogen Risk Assessment, is that the potential carcinogenicity of acrolein cannot be determined because the existing “data are inadequate for an assessment of human carcinogenic potential for either the oral or inhalation route of exposure” (EPA 2004).

1988). Copyright © National Academy of Sciences. All rights reserved. 2. Mechanism of Toxicity Allylamine has been shown to cause severe myocardial damage and vascular smooth muscle lesions in a variety of animal species upon acute exposure (Boor and Hysmith 1987). It has been used to cause lesions (proliferation of smooth muscle cells and fibrosis) that mimic human atherosclerosis by the oral, parenteral, inhalation, and intravenous routes (Boor et al. 1979; Boor and Hysmith 1987). Allylamine cardiovascular toxicity was shown in many mammalian species to be dependent on metabolism of allylamine by semicarbazidesensitive amine oxidase (SSAO) to acrolein, hydrogen peroxide, and ammonia (Lyles 1996).

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