Adenocarcinoma of the Esophagogastric Junction: From by Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni

By Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni

This publication bargains up to date and complete assurance of the analysis and treatment of adenocarcinoma of the esophagogastric junction (EGJ). As is suitable within the period of multidisciplinary and multimodal therapy, the contributions of all of the a variety of experts concerned cooperatively within the remedy of EGJ melanoma are completely defined. certain recognition can be paid to the importance of preneoplastic lesions, akin to Barrett esophagus. the ultimate a part of the e-book represents a surgical atlas documenting the suggestions utilized in the EGJ zone, with wonderful colour photographs and stepwise description of approaches. opposed to the heritage of the swiftly expanding prevalence in EGJ melanoma, specially obvious in Western nations, there's a desire for higher uniformity in administration recommendations, which at present fluctuate considerably the world over. This e-book presents acceptable counsel that may help all practitioners concerned about the analysis and therapy of EGJ cancers, together with surgeons, oncologists, and radiotherapists.

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Extra info for Adenocarcinoma of the Esophagogastric Junction: From Barrett's Esophagus to Cancer

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D) Specimen analyzed by expert pathologist confirms a high-grade dysplasia For early BAD, if submucosal invasion is found, the patients have to undergo surgical resection because of a substantial risk of metastasis. When the lesion invades the muscularis mucosae, a substantial risk of metastasis exits, and additional surgical resection is to be considered based on the patient’s condition. If the accurate evaluation of the specimen after complete en bloc resection confirms a tumor confined to the mucosa with negative lateral margins and without lymphovascular invasion, endoscopic resection can be curative because of the very low-risk positive lymph nodes.

D) Specimen analyzed by expert pathologist confirms a high-grade dysplasia For early BAD, if submucosal invasion is found, the patients have to undergo surgical resection because of a substantial risk of metastasis. When the lesion invades the muscularis mucosae, a substantial risk of metastasis exits, and additional surgical resection is to be considered based on the patient’s condition. If the accurate evaluation of the specimen after complete en bloc resection confirms a tumor confined to the mucosa with negative lateral margins and without lymphovascular invasion, endoscopic resection can be curative because of the very low-risk positive lymph nodes.

Lagergren J, Bergstrom R, Lindgren A et al (1999) Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. Cronin J, McAdam E, Danikas A et al (2011) Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and may represent a biomarker of histological progression in Barrett’s esophagus (BE). Rubstein JH (2014) Improving the efficiency of Barrett’s esophagus management: do biomarkers hit the mark? Rubstein JH, Vakil N, Inadomi JM (2005) The cost-­ effectiveness of biomarkers for predicting the development of esophageal adenocarcinoma.

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