Advancing Prion Science: Guidance for the National Prion by Institute of Medicine, Medical Follow-Up Agency, Committee

By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

Offers a file from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending learn to shut major gaps in current wisdom of prion ailments and strategies for strengthening the U.S. study infrastructure for learning those illnesses. Softcover. DNLM: Prion illnesses, prevention & control--United States.

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Users will need to develop ethically sound counseling and notification policies for those tested, especially to deal with positive tests. Developers will need to demonstrate and document the test’s performance rigorously enough to achieve FDA approval. Finally, a market for the product must exist, or be created, to attract commercial investment and manufacturing. These tasks are achievable with great resolve. SURVEILLANCE FOR TSEs IN THE UNITED STATES Surveillance for TSEs in humans and animals can permit the detection of potential outbreaks of known or new TSEs and the monitoring of those TSEs known to occur in the United States: CWD and scrapie in animals, and sCJD, iatrogenic CJD (iCJD), familial CJD, familial fatal insomnia, sporadic fatal insomnia, and Gerstmann-Sträussler-Scheinker disease in humans.

3: Fund research to develop novel methods for removing prions from or inactivating prions in blood products and tissues in vitro, using physical, chemical, or immune mechanisms alone or in combination. In contrast to blood, blood products, and blood derivatives, certain human tissues and hormones have been documented to transmit TSE agents from an infected human donor to a healthy human recipient. Present FDA regulations and guidance to industry have reduced the rate of this form of TSE transmission in the United States.

7 Develop new therapeutic agents, including antibodies, that either block the conversion of PrPC to PrPSc or disrupt the molecular mechanisms of pathogenesis of transmissible spongiform encephalopathies after this conversion has taken place. The most promising approach appears to be rational drug design, which begins with knowledge of the tertiary structure of the protein or molecule that the therapeutic agent will target. 1 Attract and train more investigators in prion disease research. In addition, for investigators conducting prion bioassay research, provide grants for 5- to 7-year periods.

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